Versatility and stability optimization of flow-focusing droplet generators <i>via</i> quality metric-driven design automation.

ABSTRACT: Droplet generation is a fundamental component of droplet microfluidics, compartmentalizing biological or chemical systems within a water-in-oil emulsion. As adoption of droplet microfluidics expands beyond expert labs or integrated devices, quality metrics are needed to contextualize the performance capabilities, improving the reproducibility and efficiency of operation. Here, we present two quality metrics for droplet generation: performance versatility, the operating range of a single device, and stability, the distance of a single operating point from a regime change. Both metrics were characterized in silico and validated experimentally using machine learning and rapid prototyping. These metrics were integrated into a design automation workflow, DAFD 2.0, which provides users wi

SUBMITTER: McIntyre D 

PROVIDER: S-EPMC10694034 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature