Improving detection of cystic fibrosis related liver disease using liver fibrosis assessment tools.

ABSTRACT:

Background & aims

Cystic Fibrosis related liver disease (CFLD) is the 3rd largest cause of death in Cystic Fibrosis (CF). As advances in pulmonary therapies have increased life-expectancy, CFLD has become more prevalent. Current guidelines may underdiagnose liver fibrosis, particularly in its early stages. Newer modalities for the assessment of fibrosis may provide a more accurate assessment. FibroScan is validated in assessing fibrosis for several aetiologies including alcohol and fatty liver, the CFLD cohort have an entirely different phenotype so the cut off values are not transferrable. We appraised fibrosis assessment tools to improve diagnosis of CFLD.

Methods

A prospective cohort (n = 114) of patients from the Manchester Adult Cystic Fibrosis Centre, UK were identifie

SUBMITTER: Scott JA 

PROVIDER: S-EPMC10694159 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature