<i>Helicobacter pylori</i> induces a novel form of innate immune memory via accumulation of NF-кB proteins.

ABSTRACT: Helicobacter pylori is a widespread Gram-negative pathogen involved in a variety of gastrointestinal diseases, including gastritis, ulceration, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. Immune responses aimed at eradication of H. pylori often prove futile, and paradoxically play a crucial role in the degeneration of epithelial integrity and disease progression. We have previously shown that H. pylori infection of primary human monocytes increases their potential to respond to subsequent bacterial stimuli - a process that may be involved in the generation of exaggerated, yet ineffective immune responses directed against the pathogen. In this study, we show that H. pylori-induced monocyte priming is not a common feature of Gram-negative

SUBMITTER: Frauenlob T 

PROVIDER: S-EPMC10694194 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature