The effect of perioperative antithrombin supplementation on blood conservation and postoperative complications after cardiopulmonary bypass surgery: A systematic review, meta-analysis and trial sequential analysis.

ABSTRACT:

Study objective

Antithrombin (AT) activity is reduced during cardiopulmonary bypass (CPB) surgery. Guidelines has demonstrated that perioperative AT supplementation contributed to blood conservation and prevent perioperative thrombotic complications and target organ injury owing to its role in reducing thrombin generation. But these recommends is lack of support of meta-analysis in the guidelines. This meta-analysis aims to include all the relevant randomized controlled trails (RCT) on patients who experienced cardiac surgeries with CPB and investigate the effect of perioperative AT on blood conservation and complications after cardiac surgery.

Methods

Standard published RCTs were searched from bibliographic databases to identify all evidence reporting perioperative AT suppl

SUBMITTER: Li T 

PROVIDER: S-EPMC10694320 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature