Atrophy of specific amygdala subfields in subjects converting to mild cognitive impairment.

ABSTRACT:

Introduction

Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI).

Methods

Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC). Anatomical magnetic resonance (MR) images were analyzed using a semi-automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quan

SUBMITTER: Padulo C 

PROVIDER: S-EPMC10694338 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature