Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy.

ABSTRACT:

Study question

Can we identify genetic variants associated with ectopic pregnancy by undertaking the first genome-wide association study (GWAS) leveraging two large-scale biobank initiatives?

Summary answer

We identified two novel genome-wide significant associations with ectopic pregnancy, highlighting MUC1 (mucin 1) as the most plausible affected gene.

What is known already

Ectopic pregnancy is an important cause of maternal morbidity and mortality worldwide. Despite being a common early pregnancy complication, the genetic predisposition to this condition remains understudied and no large scale genetic studies have been performed so far.

Study design, size, duration

A GWAS meta-analysis including 7070 women with ectopic pregnancy and 248 810 controls from Est

SUBMITTER: Pujol Gualdo N 

PROVIDER: S-EPMC10694401 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature