Platelets interact with CD169⁺ macrophages and cDC1 and enhance liposome-induced CD8⁺ T cell responses.

ABSTRACT: Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity. The immunomodulatory role of platelets entails interaction with pathogens, but also with immune cells including macrophages and dendritic cells (DCs), to activate adaptive immune responses. In our previous work, we have demonstrated that splenic CD169⁺ macrophages scavenge liposomes and collaborate with conventional type 1 DCs (cDC1) to induce expansion of CD8⁺ T cells. Here, we show that platelets associate with liposomes and bind to DNGR-1/Clec9a and CD169/Siglec-1 receptors in vitro. In addition, platelets interacted with splenic CD169⁺ macrophages and cDC1 and further increased liposo

SUBMITTER: Grabowska J 

PROVIDER: S-EPMC10694434 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature