Nano-modulators with the function of disrupting mitochondrial Ca²⁺ homeostasis and photothermal conversion for synergistic breast cancer therapy.

ABSTRACT: Breast cancer treatment has been a global puzzle, and apoptosis strategies based on mitochondrial Ca²⁺ overload have attracted extensive attention. However, various limitations of current Ca²⁺ nanogenerators make it difficult to maintain effective Ca²⁺ overload concentrations. Here, we constructed a multimodal Ca²⁺ nano-modulator that, for the first time, combined photothermal therapy (PTT) and mitochondrial Ca²⁺ overload strategies to inhibit tumor development. By crosslinking sodium alginate (SA) on the surface of calcium carbonate (CaCO₃) nanoparticles encapsulating with Cur and ICG, we prepared a synergistic Ca²⁺ nano-regulator SA/Cur@CaCO₃-ICG (SCCI). In vitro studies have shown that SCCI further e

SUBMITTER: Wang C 

PROVIDER: S-EPMC10694906 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature