Identification of a Novel CD8⁺ T cell exhaustion-related gene signature for predicting survival in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a major health concern, necessitating a deeper understanding of its prognosis and underlying mechanisms. This study aimed to investigate the mechanism and prognostic value of CD8⁺ T Cell exhaustion (CD8⁺ TEX)-related genes in HCC and construct a survival prognosis prediction model for patients with HCC.

Methods

CD8⁺ TEX-related genes associated with HCC prognosis were analysed and identified, and a prognostic prediction model was constructed using the 'least absolute shrinkage and selection operator' Cox regression model. Immunohistochemistry was used to verify the expression of the model genes in HCC tissues. A nomogram was constructed based on risk scores and clinical features, and its predictive

SUBMITTER: Liu K 

PROVIDER: S-EPMC10694949 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature