Identification of Hub Genes Related to Alzheimer's Disease and Major Depressive Disorder.

ABSTRACT: BackgroundAlthough many studies reported a close relationship between depression and Alzheimer's disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD). Method: The datasets were downloaded from the Gene Expression Omnibus. After screening differentially expressed genes (DEGs), gene ontology and pathway analysis were performed and protein-protein interaction, TF-target gene, and miRNA-target gene networks were established. Results: 171 DEGs of AD-related datasets and 79 DEGs shared by AD and MDD were detected. Functional analysis revealed that AD and MDD common genes were significantly enriched in circadian entrainment and long-term depression signaling pathways.

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10695082 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature