Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques.

ABSTRACT: Human immunodeficiency virus infection is characterized by dysregulation of antigen-presenting cell function and defects in cell-mediated immunity. Recent evidence suggests that impaired ability of CD4+ T cells to upregulate the costimulatory molecule CD154 is at the core of this dysregulation. To test the hypothesis that increased expression of CD154 on infected CD4+ T cells could modulate immune function, we constructed a replication-competent simian immunodeficiency virus (SIV) vector that expressed CD154. We found that this recombinant vector directed the expression of CD154 on the surface of infected CD4+ T cells and that expression of CD154 resulted in activation of B cells present in the same cultures. Experimental infection of rhesus macaques resulted in very low viral loads for th

SUBMITTER: Hodara VL 

PROVIDER: S-EPMC1069524 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature