Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1.

ABSTRACT:

Background

Obesity is associated with increased risk of cardiovascular disease, but underlying mechanisms remain elusive. Metabolic dysfunction, especially hyperglycemia, is thought to be a major contributor, but how glucose impacts vascular function is unclear. GAL3 (galectin-3) is a sugar-binding lectin upregulated by hyperglycemia, but its role as a causative mechanism of cardiovascular disease remains poorly understood. Therefore, the objective of this study was to determine the role of GAL3 in regulating microvascular endothelial vasodilation in obesity.

Methods

GAL3 was measured and found to be markedly increased in the plasma of overweight and obese patients, as well as in the microvascular endothelium of diabetic patients. To investigate causative mechanisms in cardi

SUBMITTER: Padgett CA 

PROVIDER: S-EPMC10695282 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature