Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity.

ABSTRACT: Antiviral responses are often accompanied by translation inhibition and formation of stress granules (SGs) in infected cells. However, the triggers for these processes and their role during infection remain subjects of active investigation. Copy-back viral genomes (cbVGs) are the primary inducers of the mitochondrial antiviral signaling (MAVS) pathway and antiviral immunity during Sendai virus (SeV) and respiratory syncytial virus (RSV) infections. The relationship between cbVGs and cellular stress during viral infections is unknown. Here, we show that SGs form during infections containing high levels of cbVGs, and not during infections with low levels of cbVGs. Moreover, using RNA fluorescent in situ hybridization to differentiate accumulation of standard viral genomes from cbVGs at a sin

SUBMITTER: Gonzalez Aparicio LJ 

PROVIDER: S-EPMC10695362 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature