Ketone bodies in right ventricular failure: A unique therapeutic opportunity.

ABSTRACT:

Background

Ketone bodies are pleotropic metabolites that play important roles in multiple biological processes ranging from bioenergetics to inflammation regulation via suppression of the NLRP3 inflammasome, and epigenetic modifications. Ketone bodies are elevated in left ventricular failure (LVF) and multiple approaches that increase ketone concentrations exert advantageous cardiac effects in rodents and humans. However, the relationships between ketone bodies and right ventricular failure (RVF) are relatively unexplored.

Methods

51 PAH patients were dichotomized into preserved or impaired RV function based on a cardiac index of 2.2 L/min/m². Impaired RV function patients were further segmented into intermediate or severe RV dysfunction based on a right atrial pr

SUBMITTER: Blake M 

PROVIDER: S-EPMC10695997 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature