Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.

ABSTRACT: BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis, growth and repair. They act by promoting the deposition of structural extracellular matrix proteins and by controlling the activity of matricellular proteins and TGF-β superfamily growth factors. They have also been implicated in several pathological conditions such as fibrosis, cancer, metabolic disorders and bone diseases. Despite this broad range of pathophysiological functions, the putative existence of a specific endogenous inhibitor capable of controlling their activities could never be confirmed. Here, we show that procollagen C-proteinase enhancer-2 (PCPE-2), a protein previously reported to bind fibrillar collagens and to promote their BTP-dependent maturation, is primarily a potent and specific inhib

SUBMITTER: Vadon-Le Goff S 

PROVIDER: S-EPMC10696041 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature