Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome.

ABSTRACT: Hydrogen sulfide (H₂ S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H₂ S is elevated and associated with degraded mitochondrial function. Therefore, removing H₂ S from the body as a stable oxide could be an approach to reducing the deleterious effects of H₂ S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H₂ S) to polysulfides (HS_2+n ^- ) and thiosulfate (S₂ O₃ ^2- ) by poly(ethylene glycol) hydrophilic carbon clusters (PEG-HCCs) and poly(ethylene glycol) oxidized activated charcoal (PEG-OACs), examples of oxidized carbon nanozymes (OCNs). We show that OCNs o

SUBMITTER: Derry PJ 

PROVIDER: S-EPMC10696138 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature