An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients - A study of T cells and natural killer cells.

ABSTRACT: Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of CD4⁺ T cells and increased levels of CD8⁺ T cells in peripheral blood from malignant melanoma patients compared with controls. Percentages of peripheral CD56^dimCD16⁺ NK cells were reduced and CD56^brightCD16^-KIR3⁺ NK cells were increased in malignant melanoma patients. Late stage malignant melanoma was correlated with low levels of CD4⁺ T cells and high levels of CD56^brightCD16^-KIR3⁺ NK cells. Finally, high levels of Treg

SUBMITTER: Heldager Pedersen N 

PROVIDER: S-EPMC10696160 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature