Comprehensive identification of onco-exaptation events in bladder cancer cell lines revealed L1PA2-SYT1 as a prognosis-relevant event.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC10696462 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Comprehensive identification of onco-exaptation events in bladder cancer cell lines revealed L1PA2-SYT1 as a prognosis-relevant event.
Wang Ziwei Z Ying Yidie Y Wang Maoyu M Chen Qing Q Wang Yi Y Yu Xufeng X He Wei W Li Jing J Zeng Shuxiong S Xu Chuanliang C
iScience 20231117 12
Transposable elements (TEs) can provide ectopic promoters to drive the expression of oncogenes in cancer, a mechanism known as onco-exaptation. Onco-exaptation events have been extensively identified in various cancers, with bladder cancer showing a high frequency of onco-exaptation events (77%). However, the effect of most of these events in bladder cancer remains unclear. This study identified 44 onco-exaptation events in 44 bladder cancer cell lines in 137 RNA-seq datasets from six publicly a ...[more]
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