Mortality and Morbidity Among Individuals With Hypertension Receiving a Diuretic, ACE Inhibitor, or Calcium Channel Blocker: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

The long-term relative risk of antihypertensive treatments with regard to mortality and morbidity is not well understood.

Objective

To determine the long-term posttrial risk of primary and secondary outcomes among trial participants who were randomized to either a thiazide-type diuretic, calcium channel blocker (CCB), or angiotensin-converting enzyme (ACE) inhibitor with up to 23 years of follow-up.

Design, setting, and participants

This prespecified secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), a multicenter randomized, double-blind, active-controlled clinical trial, followed up with participants aged 55 years or older with a diagnosis of hypertension and at least 1 other coronary heart dise

SUBMITTER: Yamal JM 

PROVIDER: S-EPMC10696481 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature