Prenatal tobacco exposure on brain morphometry partially mediated poor cognitive performance in preadolescent children.

ABSTRACT:

Objectives

To evaluate whether prenatal tobacco exposure (PTE) is related to poorer cognitive performance, abnormal brain morphometry, and whether poor cognitive performance is mediated by PTE-related structural brain differences.

Methods

The Adolescent Brain Cognitive Development study dataset was used to compare structural MRI data and neurocognitive (NIH Toolbox^®) scores in 9-to-10-year-old children with (n=620) and without PTE (n=10,989). We also evaluated whether PTE effects on brain morphometry mediated PTE effects on neurocognitive scores. Group effects were evaluated using Linear Mixed Models, covaried for socio-demographics and prenatal exposures to alcohol and/or marijuana, and corrected for multiple comparisons using the false-discovery rate (FDR).

R

SUBMITTER: Rodriguez Rivera PJ 

PROVIDER: S-EPMC10696570 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature