Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease.

ABSTRACT:

Background

We aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD).

Methods

Summary-level genome-wide association statistics of CAD were obtained from the CARDIoGRAMplusC4D consortium (60,801 cases and 123,504 controls) and the FinnGen study (R8, 39,036 cases and 303,463 controls). Proteome-wide Mendelian randomization (MR) analysis was conducted to identify CAD-associated blood proteins, supplemented by colocalization analysis to minimize potential bias caused by linkage disequilibrium. Two-sample MR analyses were performed to assess the associations of genetically predicted four obesity measures and 13 lifestyle factors with CAD risk and CAD-associated proteins' levels. A two-step network MR analysis was conducted

SUBMITTER: Yang F 

PROVIDER: S-EPMC10696760 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature