Dataset Information

A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.

ABSTRACT:

Background

Aflatoxins are regarded as the most potent genotoxic and carcinogenic type of mycotoxins. This meta-analysis was performed to investigate a the relation of aflatoxin B1 (AFB1) to growth measurements of infants/children, including wasting, underweight, stunting, as well as weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) z-scores.

Methods

Electronic databases of PubMed, Web of Science, and Scopus were searched to identify related publications. Effect sizes for associations were pooled using the random effects analysis. Subgroup analysis by study design, method used to assess AFB1, and adjustment for covariateswas performed to detect possible sources of heterogeneity.

Results

Pooled analysis of available data showed that AFB1 exposure was negatively associated growth z-scores, including WHZ (β = -0.02, 95%CI = -0.07 to 0.03), with WAZ (β = -0.18, 95%CI = -0.33 to -0.02), and HAZ (β = -0.17, 95%CI = -0.30 to -0.03) in infants/children. There was a remarkable heterogeneity among studies on WAZ and HAZ (P ≤ 0.001). In prospective cohort studies, AFB1 exposure was found to be significantly associated with the elevated risk of underweight (OR = 1.20, 95%CI = 1.03 to 1.40) and stunting (OR = 1.21, 95%CI = 1.11 to 1.33).

Conclusions

This meta-analysis highlighted the importance of AFB1 exposure as a potential risk factor for growth impairment in infants/children.

SUBMITTER: Nejad BG

PROVIDER: S-EPMC10696779 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.

Nejad Behnam Ghorbani BG Mostafaei Zahra Z Rezaabad Ali Balouchi AB Mehravar Fatemeh F Zarei Mahtab M Dehghani Azadeh A Estabragh Mohammad Amin Raeisi MAR Karami-Mohajeri Somayyeh S Alizadeh Hamzeh H

BMC pediatrics 20231205 1

<h4>Background</h4>Aflatoxins are regarded as the most potent genotoxic and carcinogenic type of mycotoxins. This meta-analysis was performed to investigate a the relation of aflatoxin B1 (AFB1) to growth measurements of infants/children, including wasting, underweight, stunting, as well as weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) z-scores.<h4>Methods</h4>Electronic databases of PubMed, Web of Science, and Scopus were searched to identify related publications. Effe ...[more]

PMID: 38053136

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Dataset Information

A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.

Background

Methods

Results

Conclusions

Publications

A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.

Similar Datasets

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