Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone.

ABSTRACT:

Background

Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of the uterus, its main symptoms are pain and infertility. Endometriosis often co-occurs with other conditions, which may provide insights into the origins of endometriosis.

Methods

Here a polygenic risk score phenome-wide association study of endometriosis was conducted in the UK Biobank to investigate the pleiotropic effects of a genetic liability to endometriosis. The relationship between the polygenic risk score for endometriosis and health conditions, blood and urine biomarkers and reproductive factors were investigated separately in females, males and fem

SUBMITTER: McGrath IM 

PROVIDER: S-EPMC10696845 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature