Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amyloid-beta (A[Formula: see text]) and tau. We study their effect on neuronal activity, with the aim of assessing their individual and combined impact.

Methods

We use a whole-brain dynamic model to find the optimal parameters that best describe the effects of A[Formula: see text] and tau on the excitation-inhibition balance of the local nodes.

Results

We found a clear dominance of A[Formula: see text] over tau in the early disease stages (MCI), while tau dominates over A[Formula: see text] in the latest stages (AD). We identify crucial roles for A[Formula: see text] and tau in complex neuronal dynamics and demonstrate the viability of using regi

SUBMITTER: Patow G 

PROVIDER: S-EPMC10696890 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature