Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma.

ABSTRACT:

Purpose

Vitreoretinal lymphoma is a high-grade malignant non-Hodgkin lymphoma with poor prognosis. The objective of this study was to elucidate the proteome profile of the vitreous in patients with vitreoretinal lymphoma (VRL), aiming to advance understanding of the pathophysiology of VRL.

Methods

Comprehensive proteomic analyses of vitreous humor using liquid chromatography with tandem mass spectrometry were performed for 10 patients with VRL, 10 control patients with idiopathic epiretinal membrane or macular hole, and 10 patients with ocular sarcoidosis. Differentially expressed proteins (DEPs) were identified by comparing VRL with controls and sarcoidosis, and functional pathway analysis was performed. Finally, vitreous concentrations of representative DEPs that were sign

SUBMITTER: Komatsu H 

PROVIDER: S-EPMC10697174 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature