The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts.

ABSTRACT: A central goal in neuroscience is the development of a comprehensive mapping between structural and functional brain features, which facilitates mechanistic interpretation of brain function. However, the interpretability of structure-function brain models remains limited by a lack of biological detail. Here, we characterize human structural brain networks weighted by multiple white matter microstructural features including total intra-axonal cross-sectional area and myelin content. We report edge-weight-dependent spatial distributions, variance, small-worldness, rich club, hubs, as well as relationships with function, edge length, and myelin. Contrasting networks weighted by the total intra-axonal cross-sectional area and myelin content of white matter tracts, we find opposite relationship

SUBMITTER: Nelson MC 

PROVIDER: S-EPMC10697181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature