Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems.

ABSTRACT: Implantable, bioresorbable drug delivery systems offer an alternative to current drug administration techniques; allowing for patient-tailored drug dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows for the acceleration of the design of the release systems, and for prediction of physical anomalies that are not intuitive and may otherwise elude discovery. This study investigates short-term drug release as a function of water-mediated polymer phase inversion into a solid depot within hours to days, as well as long-term hydrolysis-mediated degradation and erosion of the implant over the next few weeks. Finite difference methods are used to model spatial and temporal changes in polymer phase inversion, solidification, and hydrolysis. Modeling reveals the

SUBMITTER: Giolando PA 

PROVIDER: S-EPMC10697660 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature