Classification of Heart Failure Events by Severity: Insights From the VICTORIA Trial.

ABSTRACT:

Background

Hospitalization due to heart failure (HFH) is a major source of morbidity, consumes significant economic resources and is a key endpoint in HF clinical trials. HFH events vary in severity and implications, but they are typically considered equivalent when analyzing clinical trial outcomes.

Objectives

We aimed to evaluate the frequency and severity of HF events, assess treatment effects and describe differences in outcomes by type of HF event in VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction).

Methods

VICTORIA compared vericiguat with placebo in patients with HF with reduced ejection fraction (< 45%) and a recent worsening HF event. All HFHs were prospectively adjudicated by an independent clinical events comm

SUBMITTER: Felker GM 

PROVIDER: S-EPMC10697691 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature