Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases.

ABSTRACT: MicroRNAs (miRNAs) are the smallest class of noncoding RNAs, which widely exist in animals and plants. They can inhibit translation or overexpression by combining with mRNA and participate in posttranscriptional regulation of genes, resulting in reduced expression of target proteins, affecting the development, growth, aging, metabolism, and other physiological and pathological processes of animals and plants. It is a powerful negative regulator of gene expression. It mediates the information exchange between different cellular pathways in cellular homeostasis and stress response and regulates the differentiation, plasticity, and neurotransmission of neurons. In neurodegenerative diseases, in addition to the complex interactions between genetic susceptibility and environmental factors, miRN

SUBMITTER: Ma YM 

PROVIDER: S-EPMC10697780 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature