Syncytin-1, syncytin-2 and suppressyn in human health and disease.

ABSTRACT: In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.

SUBMITTER: Priscakova P 

PROVIDER: S-EPMC10697888 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature