The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology.

ABSTRACT: Breast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective measures for cancer prevention and cancer therapy require a detailed understanding of the individual key disease mechanisms involved and their interactions at the molecular, cellular, tissue, organ, and organism level. In that regard, the rapid progress of biomedical and toxicological research in recent years now allows the pursuit of new approaches based on non-animal methods that provide greater mechanistic insight than traditional animal models and therefore facilitate the development of Adverse Outcome Pathways (AOPs) for human diseases. We performed a systematic review of the current state of published knowledge with regard to breast cancer to identify relevant ke

SUBMITTER: von Coburg E 

PROVIDER: S-EPMC10697925 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature