Accurate image derived input function in [¹⁸F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia.

ABSTRACT:

Background

Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region. To avoid invasive blood sampling, the use of an image derived input function has been proposed. However, an accurate delineation of the blood pool region in the PET image is necessary to obtain unbiased blood activity. Here, to perform brain kinetic modeling in [¹⁸F]SynVesT-1 dynamic scans, we make use of non-negative matrix factorization (NMF) to unmix the activity signal from the different tissues that can contribute to the heart region activity, and extract only the left ventricle activity in an unbiased way. This method was implemented in dynamic [¹⁸F]SynVesT-1 scans of mice anesthetized with ei

SUBMITTER: Miranda A 

PROVIDER: S-EPMC10697927 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature