Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy.

ABSTRACT: The mystery about the mechanistic basis of disulfidptosis has recently been unraveled and shows promise as an effective treatment modality for triggering cancer cell death. However, the limited understanding of the role of disulfidptosis in tumor progression and drug sensitivity has hindered the development of disulfidptosis-targeted therapy and combinations with other therapeutic strategies. Here, we established a disulfidptosis signature model to estimate tumor disulfidptosis status in approximately 10,000 tumor samples across 33 cancer types and revealed its prognostic value. Then, we characterized disulfidptosis-associated molecular features and identified various types of molecular alterations that correlate with both drug-resistant and drug-sensitive responses to anti-tumor drugs. We

SUBMITTER: Zhao D 

PROVIDER: S-EPMC10698012 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature