Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase.

ABSTRACT:

Objectives

Present report evaluates the protective effect of geraniol on high fat diet (HFD) induced obesity in rats and also determines the molecular mechanism of it.

Methods

Rats were induced with obesity with administration of HFD for four weeks and geraniol 200 and 400 mg/kg p.o. was administered for the next four week in the respective groups. Blood glucose and oral glucose tolerance test (OGTT), lipid profile was estimated in the geraniol treated HFD induced obesity in rats. Moreover, docking study was performed to determine the specific mechanism of geraniol by targeting HMG-CoE A reductase (in silico).

Results

There was significant increase in body weight and amelioration in altered serum glucose and lipid profile were observed in the geraniol treated group th

SUBMITTER: Chand S 

PROVIDER: S-EPMC10698077 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature