Effective interactions and phase behavior of protein solutions in the presence of hexamine cobalt(III) chloride.

ABSTRACT: It is well established that deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) exhibit a reentrant condensation (RC) phase behavior in the presence of the trivalent hexamine cobalt(III) cations (Hac) which can be important for their packing and folding. A similar behavior can be observed for negatively charged globular proteins in the presence of trivalent metal cations, such as Y³⁺ or La³⁺. This phase behavior is mainly driven by charge inversion upon an increasing salt concentration for a fixed protein concentration (c_p). However, as Hac exhibits structural differences compared to other multivalent metal cations, with six ammonia ligands (NH₃) covalently bonded to the central cobalt atom, it is not clear that Hac can induce a similar phase

SUBMITTER: Senft MD 

PROVIDER: S-EPMC10698144 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature