Integrated analysis identities Rho GTPases related molecular map in patients with gastric carcinoma.

ABSTRACT: The intricate involvement of Rho GTPases in a multitude of human malignancies and their diverse array of biological functions has garnered substantial attention within the scientific community. However, their expression pattern and potential role in gastric cancer (GC) remain unclear. In this study, we successfully identified two distinct subtypes associated with Rho GTPase-related gene (RGG) through consensus clustering analysis, which exhibited significant disparities in overall survival and the tumor microenvironment. Subsequently, an extensively validated risk model termed RGGscore was meticulously constructed to prognosticate the outcomes of GC patients. This model was further assessed and validated using an external cohort. Notably, the high RGGscore group was indicative of a poorer

SUBMITTER: Ma S 

PROVIDER: S-EPMC10698149 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature