A Randomized Trial of Closed-Loop Insulin Delivery Postpartum in Type 1 Diabetes.

ABSTRACT:

Objective

This study aimed to evaluate the efficacy of closed-loop insulin delivery postpartum.

Research design and methods

In this open-label, randomized controlled trial, postpartum individuals with type 1 diabetes were randomized to hybrid closed-loop insulin delivery with the MiniMed 670G/770G system in automode or sensor-augmented pump therapy in the first 12-weeks postpartum followed by a continuation phase with closed-loop insulin delivery for all until 24 weeks postpartum.

Results

Eighteen participants (mean ± SD age 32 ± 3.5 years, diabetes duration 22 ± 7.3 years, and early pregnancy HbA1c 52 ± 6.8 mmol/mol [6.9 ± 0.9%]) completed 24 weeks of postpartum follow-up. In the randomized phase, percent time in range 70-180 mg/dL (3.9-10 mmol/L) did not differ betw

SUBMITTER: Donovan LE 

PROVIDER: S-EPMC10698209 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature