Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial.

ABSTRACT:

Objective

To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease.

Design

Parallel group, pragmatic randomised, superiority trial.

Setting

20 secondary care centres in the UK.

Participants

434 adults (>18 years) with uncomplicated symptomatic gallstone disease referred to secondary care, assessed for eligibility between August 2016 and November 2019, and randomly assigned (1:1) to receive conservative management or laparoscopic cholecystectomy.

Interventions

Conservative management or surgical removal of the gallbladder.

Main outcome measures

The primary patient outcome was quality

SUBMITTER: Ahmed I 

PROVIDER: S-EPMC10698555 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature