Manganese(II) ions suppress the transcription of the citrate exporter encoding gene cexA in Aspergillus niger.

ABSTRACT: Aspergillus niger is an important filamentous fungus used for the industrial production of citric acid. One of the most important factors that affect citric acid production is the concentration of manganese(II) ions present in the culture broth. Under manganese(II)-limiting conditions, the fungus develops a pellet-like morphology that is crucial for high citric acid accumulation. The impact of manganese(II) ions on the transcription of the major citrate exporter encoding gene cexA was studied under manganese(II)-deficient and -sufficient conditions. Furthermore, citric acid production was analyzed in overexpression mutant strains of cexA in the presence and absence of manganese(II) ions, and the influence of CexA on fungal morphology was investigated by microscopy. Tra

SUBMITTER: Reinfurt A 

PROVIDER: S-EPMC10698684 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature