Ontology highlight
ABSTRACT:
SUBMITTER: Pflug KM
PROVIDER: S-EPMC10698717 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Pflug Kathryn M KM Lee Dong W DW Tripathi Ashutosh A Bankaitis Vytas A VA Burgess Kevin K Sitcheran Raquel R
Molecular pharmaceutics 20231108 12
Glioblastoma (GBM) is a highly aggressive form of brain cancer with a poor prognosis and limited treatment options. The ALK and c-MET inhibitor Crizotinib has demonstrated preclinical therapeutic potential for newly diagnosed GBM, although its efficacy is limited by poor penetration of the blood brain barrier. Here, we identify Crizotinib as a novel inhibitor of nuclear factor-κB (NF-κB)-inducing kinase, which is a key regulator of GBM growth and proliferation. We further show that the conjugati ...[more]