Kidney shape statistical analysis: associations with disease and anthropometric factors.

ABSTRACT:

Background

Organ measurements derived from magnetic resonance imaging (MRI) have the potential to enhance our understanding of the precise phenotypic variations underlying many clinical conditions.

Methods

We applied morphometric methods to study the kidneys by constructing surface meshes from kidney segmentations from abdominal MRI data in 38,868 participants in the UK Biobank. Using mesh-based analysis techniques based on statistical parametric maps (SPMs), we were able to detect variations in specific regions of the kidney and associate those with anthropometric traits as well as disease states including chronic kidney disease (CKD), type-2 diabetes (T2D), and hypertension. Statistical shape analysis (SSA) based on principal component analysis was also used within the dis

SUBMITTER: Thanaj M 

PROVIDER: S-EPMC10698953 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature