Predictive value of CCL2 in the prognosis and immunotherapy response of glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a poor prognosis. The C-C motif chemokine ligand 2 (CCL2) has shown abnormal expression associated with progression of multiple malignancies, however, its role in predicting the prognosis and immunotherapy response of GBM remains poorly understood.

Results

CCL2 was highly expressed in GBM as analyzed by integrating CGGA, GEPIA and UALCAN online platforms, and further verified by histologic examinations, qRT-PCR analysis, and independent GEO datasets. CCL2 could serve as an independent prognostic factor for both the poor overall survival and progression-free survival of GBM patients based on TCGA data, univariate and multivariate cox analyses. Functional enrichment analysis reveale

SUBMITTER: Deng L 

PROVIDER: S-EPMC10698956 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature