Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma risk. In this study, we used Mendelian randomization (MR) analysis to explore the direction and magnitude of the causal relationship between viral infection and glioma.

Methods

We conducted a two-sample bidirectional MR analysis using genome-wide association study (GWAS) data. Summary statistics data of glioma were collected from the largest meta-analysis GWAS, involving 12,488 cases and 18,169 controls. Single-nucleotide polymorphisms (SNPs) associated with exposures were used as instrumental variables to estimate the causal relationship between glioma and t

SUBMITTER: Zhong S 

PROVIDER: S-EPMC10698979 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature