Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development.

ABSTRACT:

Background

Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is unknown. Neither are the time of occurrence and the potential inheritance patterns of BRCA1 epimutations established.

Methods

To address these questions, we analyzed BRCA1 methylation status in breast cancer tissue and matched white blood cells (WBC) from 408 patients with 411 primary breast cancers, including 66 TNBCs, applying a highly sensitive sequencing assay, allowing allele-resolved methylation assessment. Furthermore, to assess the time of origin and the characteristics of normal cell BRCA1 methylation, we analyzed umbilical cord blood of 1260 newborn gi

SUBMITTER: Nikolaienko O 

PROVIDER: S-EPMC10698991 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature