Single-cell transcriptomic atlas of goat ovarian aging.

ABSTRACT:

Background

The ovaries are one of the first organs that undergo degenerative changes earlier in the aging process, and ovarian aging is shown by a decrease in the number and quality of oocytes. However, little is known about the molecular mechanisms of female age-related fertility decline in different types of ovarian cells during aging, especially in goats. Therefore, the aim of this study was to reveal the mechanisms driving ovarian aging in goats at single-cell resolution.

Results

For the first time, we surveyed the single-cell transcriptomic landscape of over 27,000 ovarian cells from newborn, young and aging goats, and identified nine ovarian cell types with distinct gene-expression signatures. Functional enrichment analysis showed that ovarian cell types were involved

SUBMITTER: Xu D 

PROVIDER: S-EPMC10699009 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature