Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility.

ABSTRACT:

Background

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics.

Methods

Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by

SUBMITTER: Moraes ACCG 

PROVIDER: S-EPMC10699025 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature