Causal associations between liver traits and Colorectal cancer: a Mendelian randomization study.

ABSTRACT:

Objective

This study aimed to investigate the causal associations between several liver traits (liver iron content, percent liver fat, alanine transaminase levels, and liver volume) and colorectal cancer (CRC) risk using a Mendelian randomization (MR) approach to improve our understanding of the disease and its management.

Methods

Genetic variants were used as instrumental variables, extracted from genome-wide association studies (GWAS) datasets of liver traits and CRC. The Two-Sample MR package in R was used to conduct inverse variance weighted (IVW), MR Egger, Maximum likelihood, Weighted median, and Inverse variance weighted (multiplicative random effects) MR approaches to generate overall estimates of the effect. MR analysis was conducted with Benjamini-Hochberg method-c

SUBMITTER: Ni Y 

PROVIDER: S-EPMC10699049 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature