Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis.

ABSTRACT:

Background

Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited therapeutics. Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD⁺), has been recently reported to be protective in sepsis; however, its therapeutic effects remain to be determined. This study sought to investigate the therapeutic effects of NMN in septic organ failure and its underlying mechanisms.

Methods

Sepsis was induced by feces-injection-in-peritoneum in mice. NMN was given after an hour of sepsis onset. Cultured neutrophils, macrophages and endothelial cells were incubated with various agents.

Results

We demonstrate that administration of NMN elevated NAD⁺ levels and redu

SUBMITTER: Cao T 

PROVIDER: S-EPMC10699070 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature