Novel aminoacylases from Streptomyces griseus DSM 40236 and their recombinant production in Streptomyces lividans.

ABSTRACT: Amino acid-based surfactants are valuable compounds for cosmetic formulations. The chemical synthesis of acyl amino acids is conventionally performed by the Schotten-Baumann reaction using fatty acyl chlorides, but aminoacylases have also been investigated for use in biocatalytic synthesis with free fatty acids. Aminoacylases and their properties are diverse; they belong to different peptidase families and show differences in substrate specificity and biocatalytic potential. Bacterial aminoacylases capable of synthesis have been isolated from Burkholderia, Mycolicibacterium, and Streptomyces. Although several proteases and peptidases from S. griseus have been described, no aminoacylases from this species have been identified yet. In this study, we investigated two novel enzymes produced by

SUBMITTER: Haeger G 

PROVIDER: S-EPMC10699109 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature