Population-level effectiveness of pre-exposure prophylaxis for HIV prevention among men who have sex with men in Montreal (Canada): a modelling study of surveillance and survey data.

ABSTRACT:

Introduction

HIV pre-exposure prophylaxis (PrEP) has been recommended and partly subsidized in Québec, Canada, since 2013. We evaluated the population-level impact of PrEP on HIV transmission among men who have sex with men (MSM) in Montréal, Québec's largest city, over 2013-2021.

Methods

We used an agent-based mathematical model of sexual HIV transmission to estimate the fraction of HIV acquisitions averted by PrEP compared to a counterfactual scenario without PrEP. The model was calibrated to local MSM survey, surveillance, and cohort data and accounted for COVID-19 pandemic impacts on sexual activity, HIV prevention, and care. PrEP was modelled from 2013 onwards, assuming 86% individual-level effectiveness. The PrEP eligibility criteria were: any anal sex unprotected by c

SUBMITTER: Doyle CM 

PROVIDER: S-EPMC10699110 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature